Ngwaahịa
Dexamethasone
Usoro nhazi
Anụ ahụ
Ọdịdị: ọcha ntụ ntụ
Njupụta: 1.1283
Ebe mgbaze: 262-264°C
Ebe esi mmiri: 568.2± 50.0°C
Data nchekwa
Ụdị ihe egwu: ngwa ahịa izugbe
Ngwa
A na-ejikarị ya eme ihe maka mgbochi mkpali na mgbochi nrịanrịa.Ọ dị mma maka ọrịa ogbu na nkwonkwo na ọrịa collagen ndị ọzọ.
Emebere Dexamethasone (DXMS) na nke izizi na 1957 wee depụta ya na Ndepụta Ọkọlọtọ Ọgwụ dị mkpa nke WHO dịka otu n'ime ọgwụ ndị dị mkpa maka sistemu ahụike ọha.
Na June 16, 2020, WHO kwuru na nsonaazụ nnwale ụlọ ọgwụ izizi na United Kingdom gosipụtara na dexamethasone nwere ike ịzọpụta ndụ ndị ọrịa nwere oke oyi oyi neocoronary, na-ebelata ọnwụ ihe dị ka otu ụzọ n'ụzọ atọ maka ndị ọrịa nwere ikuku ventilashị yana ihe dị ka otu ụzọ n'ụzọ ise maka ndị ọrịa. naanị oxygen.
Dexamethasone bụ corticosteroid sịntetik nke enwere ike iji gwọọ ọnọdụ dịgasị iche iche, gụnyere ọrịa rheumatic, ọnọdụ akpụkpọ ahụ ụfọdụ, allergies siri ike, ụkwara ume ọkụ, ọrịa na-adịghị ala ala obstructive pulmonary, laryngitis ezi omume, ụbụrụ ụbụrụ, na ikekwe na ngwakọta na ọgwụ nje na ndị ọrịa nwere ọrịa. ụkwara nta.O nwere ogo afọ ime nke C na United States, nke chọrọ nyocha na ịdị irè nke ọgwụ ahụ karịrị mmetụta ndị dị na ya tupu e nwee ike inye ya, yana ọkwa A na Australia, nke na-egosi na a na-ejikarị ya na ụmụ nwanyị dị ime. na ọ nweghị ihe akaebe nke mmerụ nwa ebu n'afọ.
Mmetụta ọgwụ
Dexamethasone, nke a makwaara dị ka flumethasone, fluprednisolone, na dexamethasone, bụ glucocorticoid.Ihe mmepụta ya gụnyere hydrocortisone, prednisone, wdg. Mmetụta ọgwụ ya bụ nke kachasị mgbochi mkpali, mgbochi nsị, ihe nfụkasị ahụ na mgbochi rheumatic, a na-ejikwa ya na omume ụlọ ọgwụ.Plasma ya T1/2 bụ nkeji 190 na anụ ahụ T1/2 bụ ụbọchị 3.Ọnụ ọgụgụ kasị elu n'ọbara dexamethasone sodium phosphate ma ọ bụ dexamethasone acetate na-erute na elekere l na awa 8 n'otu n'otu mgbe ịgba ọgwụ mgbochi intramuscular gasịrị.Ọnụego njikọ protein plasma nke ngwaahịa a dị ala karịa nke corticosteroids ndị ọzọ.Ọrụ mgbochi mkpali nke 0.75 mg bụ 5 mg nke prednisolone.Adrenocorticosteroids, mgbochi mkpali, mgbochi-allergic na mgbochi-egbu egbu mmetụta dị ike karịa nke prednisone, na mmetụta nke sodium njigide na potassium excretion dị nnọọ ìhè.
1. Mmetụta mgbochi mkpali: Ọ nwere ike belata ma gbochie nzaghachi anụ ahụ na mbufụt, si otú a na-ebelata ngosipụta nke mbufụt.Hormones na-egbochi nchịkọta nke mkpụrụ ndụ na-egbuke egbuke, gụnyere macrophages na leukocytes, na saịtị nke mbufụt ma na-egbochi phagocytosis, ntọhapụ nke enzymes lysosomal, na njikọ na ntọhapụ nke ndị ogbugbo kemịkalụ nke mbufụt.
2. Mmetụta immunosuppressive: gụnyere igbochi ma ọ bụ igbochi mmeghachi omume mgbochi nke cell, na-egbu oge mmeghachi omume nfụkasị ahụ, ibelata ọnụ ọgụgụ nke T lymphocytes, monocytes, na eosinophils, na-ebelata ikike nke immunoglobulins na ndị na-anabata elu cell, na igbochi njikọ na ntọhapụ nke interleukins. , si otú ahụ na-ebelata ngbanwe nke T lymphocytes na lymphoblasts na ibelata mgbasawanye nke nzaghachi mgbochi mbụ.Ọ na-ebelata ngafe nke ogige ndị na-alụso ọrịa ọgụ site na akpụkpọ ahụ okpuru ulo ma na-ebelata mkpokọta ihe mejupụtara ya na immunoglobulins.
A na-etinye ya ngwa ngwa site na traktị GI, yana plasma T1/2 nke nkeji 190 na anụ ahụ T1/2 nke ụbọchị 3.A na-enweta ọkwa kachasị elu n'ọbara na elekere 1 na awa 8 ka ịgbanye ọgwụ intramuscular nke dexamethasone sodium phosphate ma ọ bụ dexamethasone acetate, n'otu n'otu.Ọnụego njikọ protein plasma nke ngwaahịa a dị ala karịa corticosteroids ndị ọzọ, yana ọrụ mgbochi mkpali nke ngwaahịa a 0.75 mg bụ 5 mg nke prednisolone.
