Ngwaahịa
5-Fluorocytosine
Usoro nhazi
Anụ ahụ
Ọdịdị: White ntụ ntụ
Njupụta: 1.3990 (atụmatụ)
Ebe mgbaze: 298-300 Celsius (dec.) (ọkụ.)
Ebe esi nri.
Refractivity
Ebe mgbari.
Data nchekwa
Otu dị ize ndụ.
Nọmba njem ngwongwo dị ize ndụ.
Ngalaba mbukota.
Ngwa
A na-eji Flucytosine site n'ọnụ maka ọgwụgwọ ọrịa siri ike nke ụdị Candida ma ọ bụ Cryptococcus neoformans nwere ike ịkpata.A pụkwara iji ya mee ihe maka ọgwụgwọ chromomycosis (chromoblastomycosis), ma ọ bụrụ na nsogbu ndị nwere ike ịkpata ọrịa ahụ.Agaghị eji Flucytosine dị ka onye naanị ya na ọrịa fungal na-eyi ndụ egwu n'ihi mmetụta antifungal na-adịghị ike yana mmepe ngwa ngwa nke nguzogide, kama yana ngwakọta na amphotericin B na / ma ọ bụ azole antifungals dị ka fluconazole ma ọ bụ itraconazole.Enwere ike iji flucytosine gwọọ obere ọrịa dịka cystitis candidal.Na mba ụfọdụ, ọgwụgwọ na-eji nwayọọ nwayọọ infusions intravenous ihe karịrị otu izu bụkwa nhọrọ ọgwụgwọ, karịsịa ma ọ bụrụ na ọrịa na-eyi ndụ egwu.
Ọrịa fungal siri ike nwere ike ime n'ime ndị na-enweghị mgbochi.Ndị a na-erite uru na ọgwụgwọ nchikota gụnyere flucytosine, mana mmetụta nke akụkụ-mmetụta ọgwụgwọ ngwakọta, karịsịa na amphotericin B, nwere ike ịdị elu.
A na-eji 5-Fluorocytosine na-agwọ ọrịa fungal nke Cryptococcus na Candida kpatara, dị ka fungal sepsis, endocarditis, meningitis, na ndị na-ahụ maka ọgwụ nje maka ngụgụ na ọrịa urinary tract.
Njirimara
Ngwaahịa a nwere nnukwu ọrụ antifungal megide Candida spp.na Candida spp.ma nweekwa ọrụ antibacterial megide Bacillus spp.na Mycobacterium spp.Ngwaahịa a bụ antibacterial na obere ntinye uche na fungicidal na nnukwu mkpokọta.Usoro nke ime ihe bụ igbochi njikọ nke fungal nucleic acid.Ero dị mfe imepụta nguzogide ngwaahịa a.
Mkpachapụ anya
Ejikọtara ya na amphotericin B, ọ nwere mmetụta synergistic, ma ọ nwere ike belata nsị nke ngwaahịa a site na akụrụ ma mee ka ntinye ọbara dịkwuo elu, nke nwere ike ime ka mmeghachi omume na-egbu egbu na akụrụ na usoro ọbara.Ya mere, ekwesịrị ileba anya na ntinye ọbara kacha elu na 50-75μg / ml, ọ bụghị karịa 100μg / ml;iji ndị na-egbochi ụmị ọkpụkpụ nwere ike ịbawanye nsí hematologic nke ngwaahịa a.
Ngwaahịa a nwere ike ime ka ① ọgbụgbọ, afọ ọsịsa, ọkụ ọkụ, wdg;② mmebi imeju, ihe na-egosi ọrụ imeju dị elu, kamakwa hepatomegaly ma ọ bụ ọbụna necrosis imeju;③ myelosuppression leukocyte na mbelata platelet, mgbe ụfọdụ nwere ike ibute cytopenia ọbara dum.A kọwokwa ụkọ granulocytic leukocyte na-egbu egbu na anaemia na-ebelata;④ ihunanya, isi ọwụwa na vertigo ka akọkwara.Ya mere, jiri nlezianya mee ihe na ndị ọrịa nwere ọrịa imeju ma ọ bụ gbasara akụrụ, ọrịa ọbara, na nkwụsị nke ụmị ọkpụkpụ.Ekwesịrị ịlele foto dị n'akụkụ ọbara, ọrụ imeju na akụrụ na usoro mmamịrị oge niile mgbe ị na-eji ngwaahịa a.Ọ nwere mmetụta teratogenic na nyocha anụmanụ, ekwesịrị iji nlezianya mee ihe na ụmụ nwanyị dị ime.
Mmeghachi omume na-adịghị mma gụnyere transaminases dị elu, alkaline phosphatase, mgbaàmà eriri afọ, leukopenia, anaemia, thrombocytopenia, nkwarụ gbasara akụrụ, isi ọwụwa, mbelata anya nhụsianya, anya nhụsianya, ịnụ ihe, dyskinesia, mbelata ọbara potassium, ụkpụrụ calcium na phosphorus, na mmeghachi ahụ nfụkasị (dịka ọmụmaatụ ọkụ ọkụ). .
