Ngwaahịa
3,3'- diindolylmethane
Nkọwa
3,3'-diindolylmethane bụ etiti ọgwụ;Enwere ike ịchọta ya na phytochemicals eke nke Cruciferae Plants, ngwaahịa mmeghachi omume acid catalyzed, indole-3-methanol;Ọ nwere ọrụ nke onye na-ahụ maka mgbochi tumor;N'okpuru ọnọdụ nke itinye uche dị oke elu, ihe nrụpụta ahụ nwere ike ọ bụghị naanị mee ngwangwa apoptosis nke mkpụrụ ndụ kansa mmadụ, mana ọ na-echekwa ụzọ iji kpalite apoptosis nke mkpụrụ ndụ kansa mmadụ;Chemicalbookdim na-ebute mgbochi G1 cell mgbanaka na mkpụrụ ndụ cancer ara mmadụ MCF-7 site na usoro na ntinye okwu;Dim bụ onye na-egbochi mitochondrial h +-atpase;Dị ka onye na-akwalite uto osisi ọhụrụ, a na-eji dim na ihe ndị ọzọ eme ihe na nyocha usoro eco-friendly.
Ozi ngwaahịa
Nọmba Cas: 1968-05-4
Ịdị ọcha: ≥98%
Ụdị usoro: C17H14N2
Formula Wt.: 246.31
Aha Kemịkal: 3,3'-Diindolylmethane
Synonym: 3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl); Osisi:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE
Ebe mgbaze: 167 Celsius
Ebe esi mmiri: 230 Celsius
Solubility: Chloroform (Sparingly), methanol (obere)
Ọdịdị: Apụghị-acha ọcha ntụ ntụ
Mbupu na Nchekwa
Nkwụsi ike nchekwa akwadoro okpomọkụ nchekwa -20°C.
Nkwadebe Ebe indole (1.17 g, 10 mmol), CTAB (50% mol) na oxalic acid (50% mol) na 25 ml otu olu gbara gburugburu-ala flask, tinye 5 ml mmiri deionized, kpalie nke ọma maka 5 min. tinye mmiri formaldehyde ngwọta (0.38 g ngwọta, 5 mmol formaldehyde) dropwise.Meghachi omume maka awa 3 na ụlọ okpomọkụ ma kwụsị mmeghachi omume ahụ.A na-ewepụta ihe ngwọta mmeghachi omume na 15 ml nke ethyl acetate n'akụkụ atọ, a na-anakọta usoro organic ma kpoo ya na Na2SO4 anhydrous maka awa 5.E wepụrụ ihe mgbaze ahụ n'okpuru nrụgide dị ntakịrị na recrystallized site na ngwakọta nke methanol na mmiri (methanol/H2ChemicalbookO = 10/1) iji nye ọcha siri ike 3,3'-diindolylmethane na 85% mkpụrụ.Bioactivity3,3'-Diindolylmethane (DIM) bụ isi mgbaze ngwaahịa nke indole-3-carbinol, nke nwere ike na-egbochi ọrịa cancer na akwụkwọ nri cruciferous.3,3'-Diindolylmethane (DIM) bụ onye mmegide siri ike dị ọcha nke androgenreceptor (AR) .
Nnyocha ọmụmụ na vitro egosila na DIM bụ onye na-ahụ maka redio dị irè na mbelata, na-eme site na-akpali akpali nke ATM-drive DDR-dị ka nzaghachi yana NF-κB lanarị signaling.DIM nwere ike igbochi tumor cell mbuso agha, angiogenesis, mmụba na ịkpata apoptosis site n'ịgbanwe ụzọ mgbaàmà. dị ka AKT, NF-κB na FOXO3.Ọ nwekwara ike igbochi okwu mkpụrụ ndụ nke estrogen na-ebute ma kpalite nrụgide reticulum endoplasmic.chemicalbookDIM nwere ike gbanwee estrogen metabolism na imegide estrogen na androgen receptor ọrụ.Na vivo ọmụmụ egosila na DIM dị irè megide radieshon sistemu mgbe ọtụtụ nchịkwa gasịrị.N'ime ule vivo, DIM nyere nchebe radieshon ma ọ bụ mbelata.Na anụ ahụ nkịtị, DIM na-arụ ọrụ ATM.Enwere ike inye dIM ụmụ oke site na ndochi ọnụ (250 mg / kg) nwere nnukwu bioavailability na enweghị nnukwu t.
