Ngwaahịa
Polyinosinic acid - polycytidylic acid
Usoro nhazi
Anụ ahụ
Ọdịdị: ọcha ma ọ bụ na-acha ọcha ntụ ntụ
Njupụta.
Ebe mgbaze.
Ebe esi nri.
Refractivity
Ebe mgbari.
Data nchekwa
Otu dị ize ndụ.
Nọmba njem ngwongwo dị ize ndụ.
Ngalaba mbukota.
Ngwa
A maara Poly I: C ka ya na ndị na-anabata ihe dị ka 3 (TLR3) na-emekọrịta ihe, nke a na-egosipụta na akpụkpọ anụ endosomal nke B-cell, macrophages na sel dendritic.Poly I:C dị ka RNA nwere eriri abụọ, nke dị na ụfọdụ nje ma bụrụ ihe na-akpali akpali nke “eke” nke TLR3.Ya mere, Poly I: C nwere ike were ya dị ka analog sịntetik nke RNA nwere eriri abụọ ma bụrụ ngwá ọrụ a na-ejikarị eme nchọpụta sayensị gbasara usoro ahụ ji alụso ọrịa ọgụ.
Njirimara
Ngwaahịa a bụ inducer interferon sịntetik, nke bụ polyribonucleotide nwere eriri abụọ nke mejupụtara polyinosinic acid na polycytidylic acid.Ebe ọ bụ na interferon bụ ụdị-kpọmkwem, ọ na-esiri ike ịkwadebe nnukwu ọnụọgụ maka ngwa ụlọ ọgwụ, n'ihi ya, a na-ejikarị ya dị ka ihe na-eme ka interferon na-eme ka interferon pụta.Na mgbakwunye, polyinosinic acid ka nwere ọrụ nke adjuvant nke na-alụso ọrịa ọgụ, nke nwere ike kpalie sistemu reticuloendothelial, kwalite ọrụ phagocytic nke phagocytes, kwalite nguzobe nke ọgwụ nje, na-akpali mmeghachi omume allograft na mmeghachi ahụ nfụkasị egbu oge.Ọ nwere mmetụta antiviral na antitumor sara mbara.
Na-eji na njikọ usoro
Nchịkọta
Polycytidylic acid, nke a makwaara dị ka polyinosinic acid, polyhypoxanthine nucleotide na polycytidine nucleotide, bụ otu n'ime polynucleotide, nke nwere eriri polynucleotide nke nwere polyinosinic acid na polycytidylic acid, nke nwere àgwà decolorization na agbaze, ma kwụsie ike na -20 ℃. .
Mmetụta ọgwụ
1. Polyinosinic acid nwere mmetụta nkwalite dị mma na mgbochi ahụ kpọmkwem na nke na-abụghị nke a kapịrị ọnụ.
(1) Polymyocytes na-akwalite ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ
(2) Polymyocytes na-akwalite nzuzo nke cytokines dị iche iche
(3) Ntinye protein Mx site na polymyocytes
(4) Polymyocytes na-akwalite mmepụta nke ọgwụ nje na vivo
2. Mgbochi nje mmetụta nke polymyocytes
Nnwale in vitro, ule anụmanụ na nnwale ụlọ ọgwụ mmadụ egosila na polymyxins nwere mmetụta dị iche iche nke antiviral, gụnyere nje virus yellow fever, encephalomyelitis virus, Rift Valley fever virus, Avian influenza virus, hepatitis virus, AIDS nje, ụkwụ-na-ọnụ. ọrịa nje, nje conjunctivitis, nje ọkụ ọkụ dị mfe, nje Mengo, nje pox, nje myocarditis, nje Aleutian, coxsackievirus, wdg. E gosila na mgbochi mgbochi nke Polymyxa dị mma karịa ọgwụgwọ ọgwụgwọ nke ọrịa nje.
Ngwa
1.A homopolymer okpukpu abụọ nke enwere ike iji dị ka ihe atụ RNA iji mụọ akara ngosi cell na ọkwa nke TLR3 na-amata RNA okpukpu abụọ, nke bụkwa isi ihe na-eme ka mmeghachi omume mgbochi na nje virus.
2.Paired na polyinosinic acid na-etolite polyinosinic cell, eji maka ọgwụgwọ nke viral ịba ọcha n'anya, herpes zoster, herpes simplex keratitis, herpes stomatitis, ọrịa hemorrhagic fever, wdg.
3. Ọ nwere mmetụta adjuvant nke na-alụso ọrịa ọgụ, na-akpali sistemu reticuloendothelial, na-eme ka phagocytosis dịkwuo mma, na-eme ka e guzobe mgbochi mmadụ, na-akpali mmeghachi omume allograft na oge mmeghachi omume nfụkasị ahụ.Ọ nwere mmetụta antiviral sara mbara na mmetụta antitumor.A na-ejikarị ya eme ihe maka: mgbochi ma ọ bụ ọgwụgwọ nke ọrịa nje, ọgwụgwọ herpes zoster, herpetic keratitis, viral ịba ọcha n'anya.Adjuvant ọgwụgwọ nke etuto ahụ.Mmeghachi omume ọjọọ na-agụnyekarị hypothermia na-adịru nwa oge na onye ọ bụla nwere oke ahụ ọkụ karịa 38 ℃, nke na-agbadakarị n'onwe ya n'ime ụbọchị 1-2.Ọ bụrụ na ahụ ọkụ anaghị ebelata n'ime ụbọchị 2, a ga-akwụsị ọgwụ ahụ ozugbo.A na-ahụkwa adịghị ike, ọnụ nkụ, isi ọwụwa, ọgbụgbọ, wdg.
