Ngwaahịa
Doxifluridine
Usoro nhazi
Anụ ahụ
Ọdịdị: White Solid
Njupụta: 1.3751 (atụmatụ)
Ebe mgbaze: 188-192 Celsius (ọkụ)
Ntụgharị akọwapụtara: d25 +18.4° (c = 0.419 N'ime mmiri)
Ntugharị: 20 ° (c = 1, H2o)
Ọnọdụ nchekwa: ikuku ikuku, okpomọkụ ụlọ
Ihe na-akpata acidity (pka): 7.4 (na 25 ℃)
Data nchekwa
Ụdị ihe ize ndụ: Ngwaahịa adịghị ize ndụ
Ụgbọ njem ngwa ahịa dị ize ndụ:
Ụdị nkwakọ ngwaahịa:
Ngwa
1. Dị ka prodrug nke 5-Flurouridine.Pyrimidine nucleoside nke fluorinated nwere ọrụ cytostatic.A na-eji ọgwụ eme ihe maka ọrịa kansa afọ, ọrịa cancer colorectal, ọrịa ara ara, ọnụego remission nwere ike iru karịa 30%
2. Dị ka onye etiti maka ọgwụ antitumor Fluorouracil
Okwu mmalite maka ojiji
1. Fluorouracil dabeere antitumour agents bụ ihe mmalite nke fluorouracil.Enzyme thymidine phosphorylase, nke dị na anụ ahụ tumor, na-arụ ọrụ na ya iji mee ka ọ ghọọ fluorouracil na akpụ ahụ, si otú a na-enwe mmetụta mgbochi tumor.Ọ nwere mgbochi mgbochi tumor siri ike na nsi dị ala.A na-eji ya n'ụlọ ọgwụ maka ọrịa kansa afọ, ọrịa cancer colorectal na ọrịa ara ara, yana ọnụego remission ruru 30% ma ọ bụ karịa.
2. Ọgwụ etiti.
3. Ọ bụ onye na-ahụ maka antitumor, ọgwụ precursor nke fluorouracil (5-FU), nke a na-agbanwe n'ime fluorouracil n'efu site na omume pyrimidine nucleoside phosphorylase na anụ ahụ tumo, si otú a na-egbochi biosynthesis nke DNA na RNA na mkpụrụ ndụ tumo ma gosipụta ya. mmetụta antitumor.Ebe ọ bụ na ọrụ nke enzyme a dị elu karịa anụ ahụ nkịtị, ntụgharị nke 5-FU n'ime 5-FU na anụ ahụ tumo bụ ngwa ngwa ma họrọ maka etuto ahụ.A na-eji ya na ọgwụgwọ nke ara, afọ na ọrịa kansa ma nwee obere nsị.
