Ngwaahịa
Bucladesine
Usoro nhazi
Njirimara anụ ahụ
Ọdịdị: White siri ike crude ngwaahịa
Ọnọdụ nchekwa: -20C
Solubility H2O: 50 mg / ml
Data nchekwa
Ọ bụ nke ngwaahịa nkịtị
Ngwa
Dibutyryl cyclic adenosine monophosphate sodium bụ ihe sitere na cyclic adenosine monophosphate, nke a na-eji na-agwọ ujo cardiogenic na nkụda obi.Na 1999, Dibutyryl cyclic adenosine monophosphate sodium ude e mepụtara iji gwọọ ọrịa akpụkpọ na ọnya akpụkpọ.
Nkwadebe nke sodium dibutyryl cyclophosphate adenosine: Na flask nke nwere cyclophosphate adenosine jiri nwayọọ nwayọọ tinye mmiri mmiri sodium hydroxide ngwọta (3 mol / L) dropwise, usoro a na-achịkwa okpomọkụ, wedata ọkụ ọkụ na ụlọ okpomọkụ, gbanwee pH na 7 ~ 8 na ngwọta HCl ( 20%), gbakwunye mmiri ozuzo ethanol anhydrous nke ọcha siri ike, filtration, ihicha iji nweta nnu sodium siri ike na-acha ọcha;nnu sodium na n-butyl anhydride n'okpuru nchebe nke N2 okpomọkụ na mmeghachi omume 140 ℃.Nyochaa TLC, mmeghachi omume ahụ zuru oke wee wedata ya na ụlọ okpomọkụ, jiri nwayọọ nwayọọ tinye methyl tert-butyl ether, usoro mkpali siri ike, Chemicalbook iji nweta ngwaahịa siri ike na-acha ọcha.Ngwakọta nke methyl tert-butyl ether na acetone ka eweghachiri iji nweta ngwaahịa ebu n'uche na-acha ọcha.Ọrụ nduDibutyryl-cAMP (Bucladesine,dbcAMP) bụ ihe na-eme ka PKA na-eme ka cell nwee ike ime ihe na-eme site n'iṅomi cAMP endogenous.Dibutyryl-cAMP(Bucladesine) bụkwa ihe mgbochi phosphodiesterase (PDE).
Ọmụmụ in vitro: Dibutyryl-cAMP na-egbochi nnabata glucose neuronal site na ịgbalite PKA.N'ime hepatocytes oke nwere omenala, Dibutyryl-cAMP na-egbochi okwu nitric oxide synthase inducible na ọrụ njikọ NF-kappaB.dibutyrChemicalbookyl-cAMP na-egbochikwa TNFalpha mkpado cell apoptosis site na igbochi mmechi FADD.
N'ime ọmụmụ ihe vivo: N'ime ụdị òké, Bucladesine (600nM / òké, ip) tụgharịrị zinc chloride na ụzọ acetate butere mmebi nchekwa nchekwa nchekwa evasive.
